Enugu Rangers have been drawn against two-time champions CS Sfaxien of Tunisia in the CAF Confederation Cup last 16.
The Nigerian club will host Sfaxien in the first leg during the weekend of May 18.
And DR Congo giants TP Mazembe have received a fair draw against Mozambique club Liga Muculama.
Mazembe will be home in the first leg next weekend in Lubumbashi.
Rangers and Mazembe are part of the eight teams that fell at the CAF Champions League pre-group stage over the weekend and were relegated to the Confederation Cup.
Meanwhile in the rest of the other last 16 draws, Saint George of Ethiopia face a second successive encounter with an Egyptian side after they were draw against ENPPI just two days after they were eliminated from the Champions League by Zamalek .
St George will be home in the first leg.
The draw has also served up three derbies with the big one between a Moroccan rivals FUS Rabat and FAR Rabat with the former hosting the latter in the first leg.
CA Bizertin of Tunisia have another North African derby to contend with when they play Ismaily of Egypt whom they hosts in the first leg.
The draw comes in the wake of CAB ‘s Champions League elimination at the hands of defending champions Al Ahly who beat them 2-1 last Sunday in Cairo to advance to the group stage by the same aggregate score line.
The third North African derby in the competition will see Esperance of Tunisia travel Algeria to take on JSM Bejaia next weekend.
And in the final last 16 pairings, Stade Malien will host Lydia Academic from Burundi in Bamako in the first leg while Gabonese club US Bitam travels to Algeria to take on Entente Setif.
Winners over both legs will qualify to the Confederation Cup group stage that kicks off on July 19.