Two patients die of Lassa fever in LUTH, infected doctor isolated, 100 workers under monitoring

Two patients treated for Lassa fever at the Lagos University Teaching Hospital (LUTH), Idi-Araba have died within few days of admission in the past one week.
The two patients were admitted very late and died despite efforts to salvage them.
The first was a 32-year old pregnant lady with bleeding disorder who died after a stillbirth.
Post-mortem examination had been conducted before her Lassa Fever status was eventually suspected and confirmed.
No less than 100 different hospital workers exposed to this index case are currently being monitored.
 A resident doctor from the Department of Anatomic and Molecular Pathology who took part in the autopsy was later confirmed with the disease and is currently on admission and responding well to treatment at the Isolation Ward of LUTH.
Prof Chris  Bode, the Chief Medical Director of LUTH visited the Isolation Centre of LUTH on Tuesday in company of his top management staff and spoke with the doctor and staff to boost morale and assure them of the hospital’s full support.
He enjoined all LUTH workers to maintain a heightened level of alert in the wake of this new outbreak and observe universal precautions in handling all suspected cases of this viral hemorrhagic fever.
LUTH has always worked closely with officials of the Lagos State Ministry of Health in handling a number of diseases of public importance such as rabies, cholera, Lassa fever and the recent diarrhoea disease at the Queen’s College.
Both the Lagos State Ministry of Health and the Federal Ministry of Health have responded swiftly to contain this present Lassa fever outbreak by mobilising human and material resources to trace the sources and extent of the disease, follow up on potential contacts, identify early and test suspected cases.
There are adequate materials for containment of the disease while drugs have been made available to  treat anyone confirmed with the disease. The Centre for Disease Control (CDC) in Nigeria has also been contacted. Two other suspected cases from  Lagos State are also presently admitted and quarantined while undergoing confirmatory laboratory tests.
Lassa fever is an acute febrile illness, with bleeding and death in severe cases, caused by the Lassa fever virus with an incubation period of 6-21 days. The virus, a member of the virus family Arenaviridae, is zoonotic, or animal-borne.  About 80% of human infections are without symptoms; the remaining cases have severe multiple organ disease, where the virus affects several organs in the body, such as the liver, spleen and kidneys. Lassa fever is a significant cause of severe illness and death.
It was first identified in 1969 in Nigeria. It is endemic in Benin, Guinea, Liberia, Mali, Sierra Leone, and Nigeria, with peaks in incidence closely related to seasonal patterns. However, because the rat species which carry the virus are found throughout West Africa, the actual geographic range of the disease may extend to other countries in the region.
The reservoir or host of the Lassa virus is the “multimammate rat” called Mastomys natalensis which has many breasts and lives in the bush and around residential areas. The virus is shed in the urine and droppings of the rats hence can be transmitted through direct contact, touching objects or eating food contaminated with these materials or through cuts or sores. Transmission also occurs in health facilities where infection prevention and control practices are not observed. Person to person transmission also occurs most especially when a person comes in contact with the virus in the blood, tissue, secretions or excrements of an infected individual.
Lassa fever occurs in all age groups and both sexes. Persons at greatest risk are those living in rural areas where Mastomys are usually found, especially in communities with poor sanitation or crowded living conditions. Health workers are at risk if Lassa fever is not suspected or while caring for Lassa fever patients in the absence of proper barrier nursing and infection control practices.
The onset of the disease, when it is symptomatic, is usually gradual, starting with fever, general weakness, muscle and joint pains, prostration and malaise. After a few days, headache, sore throat, muscle pain, chest pain, nausea, vomiting, diarrhoea, cough, and abdominal pain may follow. In severe cases facial swelling, fluid in the lung cavity, bleeding from the mouth, nose, vagina or gastrointestinal tract and low blood pressure may develop. Protein may be noted in the urine. Shock, seizures, tremor, disorientation, and coma may be seen in the later stages. Deafness occurs in 25% of patients who survive the disease. In half of these cases, hearing returns partially after 1-3 months. Transient hair loss and gait disturbance may occur during recovery. Patients may die from shock.
Lassa virus infections can only be diagnosed definitively in a Virology laboratory using the following tests: the reverse transcriptase polymerase chain reaction (RT-PCR) assay, testing for IgM, antigen detection tests and virus isolation by cell culture.
These tests can be done at Virology Reference Laboratory at Lagos University Teaching Hospital, Idi-Araba, Lagos.
The only known specific treatment for Lassa fever is Ribavirin which may be effective if given within the first six days of illness. It should be given intravenously for ten (10) days. Supportive treatment should include; Paracetamol, Vitamin K (Phytamenadione), Heamacel, Ringers lactate, antimalaria and antibiotics- start by I.V. If patient is severely anaemic, consider transfusion.
There is currently no vaccine that protects against Lassa fever.
Prevention of the fever relies on promoting good “community hygiene” to discourage rodents from entering homes. Effective measures include storing grain and other foodstuffs in rodent-proof containers, disposing of garbage far from the home, maintaining clean households
In healthcare settings, prevention is by standard precautions where all blood and body fluids are considered potentially infectious. Standard precautions are applied to all patients at all times and in all health care settings. These include hand hygiene, use of appropriate personal protective equipment (PPE), waste disposal, cleaning and disinfection of medical equipment and environment, safe injection practices.
The CMD said: “In case of any suspected case of Lassa fever, notify the response team in LUTH on 08058019466, 08058744780, 07035521015 and 08023299445”.